Scientists Use Light And Sound To Clear Alzheimer’s Plaque In Mice

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Alzheimer’s disease disrupts the processing and transmission of information among neurons, resulting in loss of function and cell death. Concerning this, scientists have successfully managed to use only light and sound to eliminate the clusters of injurious proteins that get in the way of brain functioning.

MIT scientists in the first quarter of last year discovered that strobe lights and low-pitched buzz could be used to recover brain waves destroyed in the Alzheimer’s disease. As a result of this, it was possible to remove plaque and improve cognitive function in mice engineered to depict a potentially Alzheimer’s like behaviour in humans.

This technique is typically the use of light and sound to trigger the respective brain waves of the mice to aid in clearing the disease. However, at this point, it’s too soon to speculate the application of this approach in humans since brain waves in humans work differently from those in mice. But on the brighter side of this subject matter, these early results project a potentially cheap and drug-free method to treat the common form of dementia.

The background highlight of this approach works as described below;
Following a previous study that demonstrated the effect of flashing light 40 times per second into the eyes of engineered mice cured their version of Alzheimer’s disease. Scientists incorporated the effect of the sound of a similar frequency and were amazed by the positive results observed.

A waxy compound of protein and polysaccharides that are found deposited in tissue in amyloidosis called amyloid was reduced by the approach of combining both visual and auditory stimulation for seven days as well as the potential engagement of the prefrontal cortex. This result was confirmed by one of the MIT scientists, Li-Huei Tsai.

Moreover, it’s not the first time we hear of this approach to investigate the role played by sound in clearing the brain of the tangles and clumps of tau and amyloid proteins to manageable levels. This is because previous studies demonstrated that bursts of ultrasound could make blood vessels to leak and allow effective treatments to slip inside the brain.

The technique of using light at 40 flashes per second was limited to visual parts of the brain, excluding important areas that contribute to the creation and recovery of memory. Despite this shortcoming, the results obtained pointed on how such oscillations could potentially assist the brain to be cleared of Alzheimer’s disease.

Concerning the human brain, neurons aid in signal transmissions to generate brain waves which are most active at high oscillations speed defined as gamma-frequencies when we are very attentive or in a constant loop of memory searching to make sense of what is going on.

The application of light was a technique to facilitate the respective parts of the brain into a humming in the pivot of gamma. Also, sound aided in improving the results obtained as well as manage this in such related areas.

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